Women Speakers Database
  • Name

    Leng Siew Yeap
  • Email

  • Country/Region

  • Institute

    Shanghai Institute of Immunology
  • Career Stage

    New Faculty
  • Website

  • Research Interests

  • Profile

    Leng-Siew Yeap received her Ph.D. degree from University of Cambridge in 2010 where she worked with Azim Surani on understanding the role of an epigenetic modifier, ESET, a histone H3K9 methyltransferase, in maintaining pluripotency of mouse embryonic stem cells. She did her postdoctoral training in the laboratory of Dr. Frederick Alt at Harvard Medical School, Boston Children’s Hospital where she developed a new mouse model system and high throughput analysis to study antibody somatic hypermutation (SHM). With Fred Alt, she discovered that DNA sequence motifs are important in directing antibody evolution. Dr. Yeap moved to Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine in 2016 as a Principal Investigator. The Yeap lab continues to study the mechanisms of antibody diversification specifically mechanisms that generate potent antibodies and diseases related to antibody diversification mechanisms. Leng-Siew Yeap was a recipient of Tunku Abdul Rahman Medal (Malaysia) (best graduating student of University Malaysia Sabah), Dorothy Hodgkin Postgraduate Award (UK) and Cancer Research Institute Postdoctoral Fellowship (USA). The Yeap Lab is currently supported by National Natural Science Foundation of China (NSFC) Outstanding Young Scholar Program. In 2017, the Yeap Lab also received support from NSFC-MAECI to start a collaborative project with Roberto Chiarle from University of Turin on the Mechanisms of Resistance in Chronic Lymphocytic Leukemia.